Hydrogen sulfide and mitochondria

Hydrogen Sulfide as an Endogenous Modulator in Mitochondria and Mitochondria Dysfunction

Hydrogen sulfide (H(2)S) has historically been considered to be a toxic gas, an environmental and occupational hazard. However, with the discovery of its presence and enzymatic production through precursors of L-cysteine and homocysteine in mammalian tissues, H(2)S has recently received much interest as a physiological signaling molecule. H(2)S is a gaseous messenger molecule that has been impl...

Electrochemical hydrogen sulfide biosensors.

The measurement of sulfide, especially hydrogen sulfide, has held the attention of the analytical community due to its unique physiological and pathophysiological roles in biological systems. Electrochemical detection offers a rapid, highly sensitive, affordable, simple, and real-time technique to measure hydrogen sulfide concentration, which has been a well-documented and reliable method. This...

Bronchodilatory Effect of Hydrogen Sulfide in Rat

Objective(s) The aims of present study were to elucidate the effect of NaHS as a H2S donor on precontracted rat trachea smooth muscle, role of epithelium and nitric oxide in this action. Materials and Methods Tracheal rings from male adult Wistar rats were isolated and mounted in an organ bath containing Krebs–Henseleit solution under 1.5 g resting tension and contractions were recorded isom...

Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production.

Although many types of ancient bacteria and archea rely on hydrogen sulfide (H(2)S) for their energy production, eukaryotes generate ATP in an oxygen-dependent fashion. We hypothesize that endogenous H(2)S remains a regulator of energy production in mammalian cells under stress conditions, which enables the body to cope with energy demand when oxygen supply is insufficient. Cystathionine γ-lyas...

Biology for Physiological Hydrogen Sulfide